In this conversation with host Nicole Hemsoth Prickett, experts Wes Brewer (Oak Ridge National Lab) and Adrian Jackson (EPCC) discuss the evolving landscape of digital twins, particularly in the context of supercomputing and AI. They explore the distinctions between digital twins and traditional simulations, the real-world applications of digital twins, and the infrastructure challenges faced in their implementation. The discussion also delves into the potential of distributed digital twins and the role of AI in enhancing digital twin workflows, concluding with insights on future workloads and applications.